Myanmar Health Sciences Research Journal
Volume 30, Number 2
TITLE: Plasma Malondialdehyde Level, Serum High Sensitivity C-reactive Protein Level and Cognitive Ability in Elderly People
AUTHOR: Nay Chi Oo, Moe Phyu Phyu Aung & Ohnmar
SOURCE: Myanmar Health Sciences Research Journal, Vol. 30, No. 2, 2018
ABSTRACT: Oxidative stress and low grade inflammation are associated with cognitive impairment in aging. This study aimed to determine plasma malondi-aldehyde (MDA) level and serum high-sensitivity C-reactive protein (hs-CRP) level in three groups of elderly people with normal cognitive ability, with minor cognitive impairment and with dementia, to compare both parameters among three studied groups, and to find out the relationship between each of these two parameters and cognitive ability in all elderly people. This study was conducted in elderly people with normal cognitive ability (n=24), elderly people with minor cognitive impairment (n=22) and elderly people with dementia (n=24). Cognitive ability was assessed by Mini Mental State Examination (MMSE) and the cut-off score for dementia was MMSE ≤23, that of minor cognitive impairment was MMSE 24-27, and that of normal cognitive ability was MMSE ≥28. Plasma MDA and serum hs-CRP were determined by spectrophotometric method using thiobarbituric acid and enzyme linked immunosorbent assay, respectively. Plasma MDA level of the elderly people with dementia (2.64±0.66 µmol/l) was significantly higher than that of elderly people with normal cognitive ability (1.26±1.03 µmol/l), (p<0.001) and those with minor cognitive impairment (1.86±1.10 µmol/l), (p<0.05). There was a significant negative correlation between plasma MDA level and MMSE score (Pearson’s r=-0.469, p<0.001, n=70) in all elderly people. The median and interquartile range of serum hs-CRP level of the elderly people with normal cognitive ability, those with minor cognitive impairment and those with dementia were 2.03 (0.89-4.06), 2.95 (0.95-4.34), and 4 (1.45-8.65) mg/l, respectively. There was no significant difference in serum hs-CRP levels among three studied groups. A significant negative correlation was seen between serum hs-CRP level and MMSE score (Spearman’s ρ=- 0.247, p<0.05, n=70) in all elderly people. The present findings indicated that oxidative stress might be involved in pathogenesis of cognitive impairment but the role of low-grade inflammation in cognitive impairment was still equivocal.
SUBJECT HEADINGS: Oxidative stress, Low grade inflammation, Cognitive ability