Myanmar Health Sciences Research Journal
Volume 30, Number 2
TITLE: Relationship between Coagulation Parameters and Disease Severity in Patients with Primary Lung Cancer
AUTHOR: Khin La Pyae Tun , Win Pa Pa Naing, Myo Myint Maw, Aye Mya Khaing , Wai Wai Han, Ni Ni Win , Win Win Mar & Khin Saw Aye
SOURCE: Myanmar Health Sciences Research Journal, Vol. 30, No. 2, 2018
ABSTRACT: Activation of coagulation and fibrinolysis is frequently encountered among cancer patients. Such tumors are supposed to be associated with higher risk of invasion, metastasis and eventually worse outcome. This study was aimed to find out the relationship between coagulation parameters and diseases severity in primary lung cancer patients. A total of 103 primary lung cancer patients attending the Out-patient Department of Medical Oncology Unit, Yangon General Hospital, were involved in the study. The median age was 59 years (range from 13 to 82 years) with male to female ratio of 1.8:1. Among them, 81% of lung cancer patients had history of smoking. Regarding the primary site of the tumour, 64% (66) of cases had right sided lung cancer and 36% (3.7) had left sided tumours. Pretreatment blood coagulation tests including fibrinogen level, prothrombin time (INR) and platelet count were determined by using automated blood coagulation analyzer CA-50 Sysmex. In one year study, according to revised WHO classification of the lung tumours, 7(6.8%) of the tumours were small cell lung cancer, 51(49.5%) squamous cell carcinoma, 35(34%) adenocarci-noma, 10(9.7%) other types (large cell carcinoma and anaplastic carcino-ma). According to TNM staging, 4 cases (3.9%) were stage I, 14(13.6%) stage II, 35(34%) stage III and 50(48.5%) were stage IV. The plasma level of all coagulation tests revealed statistically significance in correlation to advanced (stage III and IV) stage of lung cancer, plasma fibrinogen level (p<0.0001), prothrombin time (p=0.007), INR (p=0.002) and platelet count (p=0.009), respectively. However, histological types of lung cancer were not significantly associated with coagulation parameters. Therefore, this study pointed out that the high levels of coagulation parameters were associated with the advanced cancer staging and these parameters might be used as the predictors for disease severity of primary lung cancer patients.
SUBJECT HEADINGS: Lung cancer, Coagulation parameters