Myanmar Health Sciences Research Journal
Volume 30, Number 2
TITLE: Screening of Microalbuminuria and Estimated Glomerular Filtration Rate in Type 2 Diabetes Mellitus for Early Detection of Renal Dysfunction
AUTHOR: Khin Aye Thin, Aye Aye Khin, Win Kalyar Kyaw, Myat Su Mon Zaw & Ei Ei Mon Aung
SOURCE: Myanmar Health Sciences Research Journal, Vol. 30, No. 2, 2018
ABSTRACT: Monitoring patients with diabetes for microalbuminuria is now standard practice. The estimated glomerular filtration rate (eGFR) equations are based on serum creatinine level. The accuracy of these equations can be affected in certain populations such as extreme of age and body size, severe malnutrition or obesity, diseases of skeletal muscle, paraplegia or quadriplegia and vegetarian diet. The study was to find out the association between microalbuminuria and eGFR in type 2 diabetes mellitus. It was a cross-sectional, descriptive and analytic study. Urine, blood and body weight from 70 cases among type 2 diabetes mellitus patients from Diabetic Clinic, Yangon General Hospital were collected. Urine microalbumin was detected by immunometric method and eGFR was calculated by Cockcroft-Gault formula. If eGFR is less than 90 ml/min, diabetic patients will have increased risk of chronic kidney disease (CKD). With the normal urine volume, less than 20 mg/l of urine albumin was normoalbuminuria, and greater than or equal to 20 mg/l of urine albumin was microalbuminuria. Mean age of patients was 56(SD=11.2 years) and mean duration of diabetes was 7 years (SD=6.8 years). Thirty-five percent of patients had microalbuminuria and they were in the risk of CKD, 19% had normoalbuminuria with risk of CKD, 19% had microalbuminuria with non-risk CKD. Normoalbuminuria and non-risk CKD patients were 27% of the study population. There was a statistical significant association between microalbuminuria and eGFR (p=0.035). Patients in the CKD risk group had more risk 2.8 times (95% CI=1.062-7.437) to suffer microalbuminuria than non-risk CKD group.
SUBJECT HEADINGS: Diabetes mellitus, Microalbuminuria, eGFR