Myanmar Health Sciences Research Journal
Volume 30, Number 1
TITLE: Plasma Malondialdehyde Level and Vibration Perception Threshold in Non-exposed Subjects and Lead-exposed Battery Workers
AUTHOR: Thura Tun Oo1*, Zaw Linn Thein2, Zarli Thant2 & Ohnmar2
SOURCE: Myanmar Health Sciences Research Journal, Vol. 30, No. 1, 2018
ABSTRACT: Lead is toxic to multiple organ systems and oxidative stress is one of the key mechanisms in lead toxicity. Long-term exposure can result in lead neuropathy, typically motor neuropathy. Peripheral sensory neuropathy caused by lead exposure is still controversial. The aim of this study was to determine and compare plasma malondialdehyde (MDA) level and vibration perception threshold (VPT) between non-exposed subjects and lead-exposed battery workers. This case-control analytical study included 28 non-exposed subjects and 28 lead-exposed battery workers of small-scale battery work-places in Insein and North Okkalapa townships. Plasma malondialdehyde level was determined by colorimetric method. The function of large myelinated peripheral sensory nerve fibers was determined by vibrometer and described as vibration perception threshold (VPT). The mean blood lead level of the lead-exposed battery workers (4.25±3.87 µg/dl) was signi-ficantly higher (p=0.007) than that of the non-exposed subjects (2.14±1.02 µg/dl). The mean plasma MDA level of lead-exposed battery workers was significantly (p<0.001) higher than that of the non-exposed subjects and their plasma MDA levels were 2.08±0.94 µmol/l and 0.9±0.43 µmol/l, respectively. Both mean values of VPT (hand and foot) in the lead-exposed battery workers were significantly higher than that of non-exposed subjects (p=0.002). There was no significant correlation between plasma MDA level and VPT measurements in the lead-exposed battery workers. Therefore, lead-induced lipid peroxidation and early abnormality in peripheral sensory nerve function could occur in the lead-exposed battery workers even at the low blood lead level but there was no evidence in relationship between lead-induced lipid peroxidation and peripheral sensory nerve impairment in lead-exposed battery workers.
SUBJECT HEADINGS: Lead, Oxidative stress, Plasma malondialdehyde, Vibration perception threshold