Myanmar Health Sciences Research Journal
Volume 30, Number 1
TITLE: Ki-67 Immunoexpression in Gestational Trophoblastic Diseases
AUTHOR: Nyein Nyein Soe*, Saw Wut Hmone, Myint Myint Nyein & Myat Mon
SOURCE: Myanmar Health Sciences Research Journal, Vol. 30, No. 1, 2018
ABSTRACT: Gestational trophoblastic diseases comprise of hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor having different biological behavior. Ki-67 is a proliferative marker used to evaluate the biological behavior of different tumors. The study was aimed to determine the Ki-67 immunoexpression in gestational trophoblastic diseases and its association in different types of gestational trophoblastic diseases. A cross-sectional, descriptive study was done on 50 cases of gestational trophoblastic diseases, histologically identified as 10 cases of partial hydatidiform mole, 23 cases of complete hydatidiform mole, 9 cases of invasive mole and 8 cases of choriocarcinoma. Immunoexpression of Ki-67 was determined by PAP immunohistochemistry. All cases showed Ki-67 immunopositivity. High Ki-67 labeling index (≥50% of Ki-67 positivity) was found in 10% of partial hydatidiform mole, 73.9% of complete hydatidiform mole, 33.3% of invasive mole and 100% of choriocarcinoma. Low Ki-67 labeling index (<50% of Ki-67 positivity) was found in 90% of partial hydatidiform mole, 26.1% of complete hydatidiform mole, 66.7% of invasive mole (p=0.000). These findings indicated that high Ki-67 labeling index was observed in gestational trophoblastic diseases having worse biological behavior such as complete hydatidiform mole and choriocarcinoma. So this study supports that Ki-67 immunoexpression might predict the biological behavior and prognosis of gestational trophoblastic diseases.
SUBJECT HEADINGS: Gestational trophoblastic diseases, Histological types, Ki-67 immunoexpression, Ki-67 labeling index