Myanmar Health Sciences Research Journal

Archives   2018

Myanmar   Health   Sciences   Research   Journal

Volume   30,  Number   1

TITLE:   Study on Protective Effects of Malaria Antibody among the Community in Malaria Endemic Areas
AUTHOR:   Moe Kyaw Myint1*, Khin Lin1, Aung Thu1, Mya Moe1, Phyu Phyu Win1, Zaw Lin2 & Kyaw Zin Thant3
SOURCE:   Myanmar Health Sciences Research Journal, Vol.30, No.1, 2018
ABSTRACT:   Malaria antibodies have been associated with transmission intensity and antibody responses are not much varied in seasonal condition. Antibody assessment is probable to provide a useful epidemiology tool. This study aimed to detect prevalence of antibody in different risk areas in different seasons. Community-based, cross-sectional descriptive study was conducted at high and moderate risk areas during rainy and dry seasons in 2012-2013. Rapid diagnostic testing was used for examination of antigens and antibodies. Microscopic examinations were done. Among total 414 participants, malaria antigens and antibodies (P. falciparum/ P. vivax) were detected in 17.9% (74) and 19.1% (79) of participants, respectively. Participants with older age (35±12.7 years) had more prevalence of antibody than younger ones (31.4±14.4 years). Mean difference was 3.6 years (p=0.040). Antibody prevalence was higher in participants of high risk areas (20.4%) than those of moderate risk areas (17.6%). Variation of antibody prevalence between rainy and dry season was less than that of antigen prevalence. In high risk areas, antibody was 25.5% in rainy season and 10.4% in dry season. Antigen prevalence had much variation with 32.9% in rainy season compared to 5.2% in dry season in high risk area. However, in moderate risk areas, antibody prevalence was 17.7% in rainy season and it remained with 16.7% in dry season. The antigen prevalence was 13.3% in rainy season and it was (0%) not found in dry season in moderate risk areas. Therefore, less seasonal variation of antibody prevalence between rainy and dry season was observed in moderate risk areas. The study concluded that protective effects of malaria antibody were observed in older age and associated with transmission intensity. Therefore, antibody assessment can probably provide useful epidemiology tool as it has less seasonal variation.
SUBJECT HEADINGS:   Malaria antibody and antigen, Seasonal variation, Endemic area

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