Myanmar Health Sciences Research Journal

Archives   2017

Myanmar   Health   Sciences   Research   Journal

Volume   29,  Number   3

TITLE:   Antihypertensive Effect of Allium sativum Linn. (Garlic) Bulb Tablets on Stage 1 Hypertensive Patients
AUTHOR:   Khine Khine Lwin, Han Win, Nu Nu Win, Tin Tin Htay, Win Pa Pa Naing, Win Win Maw, Phyu Phyu Win, Ei Ei Soe & Aye Zarni
SOURCE:   Myanmar Health Sciences Research Journal, Vol. 29, No. 2, 2017
ABSTRACT:   This study was performed to investigate the antihypertensive effect of dried bulb powder tablet of Allium sativum Linn. (garlic) on 15 stage 1 hypertensive patients attending the Out-patient Department of Traditional Medicine Hospital, Yangon. Garlic bulb tablets were prepared by tableting dried powder of bulbs with adhesive materials. After wash-out period of 3 days, the patients were treated orally with the dried bulb powder tablets (400 mg), 800 mg two times per day daily for 4 weeks. Blood pressure was monitored at baseline, 0.5 hr and hourly for 6 hrs after the first dose of the trial drug. Monitoring of blood pressure and vital signs was done on day 1, day 2, day 3 and weekly up to 4th week. Side effects were monitored on each patient follow-up. Investigations on biochemical and hematological parameters (blood for complete picture, random blood sugar, liver function test, renal function test) and ECG were done before and at the end of the study. The results showed that there were no reductions in blood pressure from baseline levels with the first dose of the trial drug. At the end of the trial, mean supine systolic pressure was significantly decreased from 140.33±1.29 mmHg (baseline) to 130±5.35 mmHg (p<0.001) whereas mean diastolic blood pressures was significantly decreased from 90.67±2.58 mmHg (baseline) to 82.33±4.17 mmHg (p<0.001). The results of laboratory investigations were within the reference normal ranges. No side effects were observed. It can be concluded that the dried powder of Allium sativum Linn. bulb had significant antihypertensive effect on stage 1 hypertensive patients.
SUBJECT HEADINGS:   Garlic, Antihypertensive activity

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