Myanmar Health Sciences Research Journal
Volume 29, Number 1
TITLE: Serum and Erythrocyte Magnesium and Insulin Sensitivity in Adult Lean and Obese Subjects
AUTHOR: Nway Htike Maw, Cho Lwin Aung, Mya Mya Thwin & Ohnmar
SOURCE: Myanmar Health Sciences Research Journal, Vol. 29, No. 1, 2017
ABSTRACT: Magnesium is required for both proper glucose utilization and insulin signaling. Alterations in cellular magnesium may occur in obesity and it contributes to insulin resistance. So, this study aimed to evaluate the relationship between serum or erythrocyte magnesium level and insulin sensitivity and beta-cell function of adult male subjects. A total of 103 apparently healthy adult male subjects between 18-60 years of age participated in this study. The subjects were divided into two groups according to BMI (obese group: BMI≥23 kg/m2 and lean group: BMI<23 kg/m2). Serum magnesium and erythrocyte magnesium levels of subjects were assessed by colorimetric method. Insulin sensitivity and beta-cell function were assessed by homeostasis model assessment method (HOMA) based on fasting blood glucose and fasting insulin level. Oxidase method was used to assess blood glucose and enzyme-linked immunosorbent assay for fasting insulin. The mean erythrocyte magnesium level of the obese subjects (n=52) (4.98±0.68 mg/dl) was significantly lower than that of the lean subjects (n=51) (5.39±0.84 mg/dl). In this study, no relationship was found between serum or erythrocyte magnesium and HOMA-IR and HOMA-β cell in both obese and lean subjects. Therefore, this study could not find out the significant relationship between serum magnesium and erythrocyte magnesium with insulin resistance (HOMA-IR) and beta-cell functions (HOMA-β) in healthy adult male subjects.
SUBJECT HEADINGS: Erythrocyte magnesium, Insulin sensitivity, Obese and lean subjects