Myanmar Health Sciences Research Journal
Volume 28, Number 2
TITLE: Effect of Triphala on Serum Total Cholesterol Level in Human Healthy Volunteers
AUTHOR: Sam Sam Htu, Hla Moe, Thein Zaw Linn, Cho Ye Myint & Khin Phyu Phyu
SOURCE: Myanmar Health Sciences Research Journal
ABSTRACT: This study was aimed to investigate the cholesterol lowering effect of Triphla as capsule dosage form in human healthy volunteers. A community- based interventional study was carried out on 40 subjects from State Pariyatti Sāsana University, Yadanarponsan Nunnery and University of Traditional Medicine from May 2012 to October 2013. The concentrated aqueous extract of Triphala was prepared as freeze-dried powder and the capsule dosage form of Triphala was prepared. The uniformity of filled weight and disintegration test were performed on the Triphala capsules. The serum total cholesterol (STC) levels after 4-6 hours from the last meal were measured serially by the ABX Pentra 400 Fully Automated Analyser on 0 week (before consumption of Triphala capsules) and at the end of 4 weeks, 6 weeks and 8 weeks after consumption of 600 mg of Triphala apsules per day. In all subjects, the STC levels (Mean±SD) was 5.62±0.32 mmol/L on 0 week and on 4 weeks, 6 weeks and 8 weeks were 5.25±0.5 mmol/L, 5.04±0.5 mmol/L and 4.83±0.46 mmol/L, respectively. The STC level was reduced by 0.365 (mean difference) at the end of 4 weeks (p<0.001), 0.575 (mean difference) at the end of 6 weeks (p<0.001) and 0.792 (mean difference) at the end of 8 weeks (p<0.001). STC levels were significantly reduced at 4 weeks, 6 weeks and 8 weeks compared to 0 week. The result from current study justified that Triphala can be used as the cholesterol lowering agent.
SUBJECT HEADINGS: Triphala, Serum total cholesterol, Human healthy volunteers