Myanmar Health Sciences Research Journal
Volume 28, Number 1
TITLE: Distribution of Helicobacter pylori Virulence Genes among Gastric Cancer and Non-cancer Dyspeptic Patients
AUTHOR: Mya Mya Aye, Wah Wah Aung, Thein Myint, Moe Myint Aung, Thuzar Myint, Aye Yin Shwe, Hay Mar Win & Wah Win Htike
SOURCE: Myanmar Health Sciences Research Journal, Vol. 28, No. 1, 2016
ABSTRACT: Helicobacter pylori, a common infectious bacterium, has been linked to chronic gastritis, peptic ulcer and gastric cancer and there is suggested to have association between H. pylori’s virulence genes and the occurrence of gastrointestinal diseases. The aim of this research was to determine the distribution of virulence genes of Helicobacter pylori among gastric cancer and non-cancer dyspeptic patients. This was a cross-sectional descriptive study including a total of 120 patients comprising 60 cancer patients and 60 non-cancer dyspeptic patients attending at the Department of Gastroenterology, Yangon General Hospital during the year 2013 and 2014. Helicobacter pylori was isolated from 25% of total cases; (30/120) and the distribution of virulence genes of isolated H. pylori strains among gastric cancer and non-cancer dyspeptic patients were carried out by polymerase chain reaction (PCR). The positive rates for the cagA, vacAs1, vacAs1a, vacAs1c, vacAm1, vacAm2, iceA1, iceA2, and babA2 genes in H. pylori of gastric cancer and non-cancer patients were 100%, 100%, 100%, 0%, 100%, 0%, 42%, 33%, 100% and 89%, 83%, 67%, 17%, 83%, 17%, 44%, 33% and 11%, respectively. There was a significant relationship between babA2 gene and gastric cancer (p=0.000), however, the other types of virulence genes of H. pylori had no statistically significant association with the clinical outcomes (p>0.05). Data from this study were expected to provide the association between virulence genes of H. pylori and the occurrence of the gastrointestinal diseases including gastric cancer.
SUBJECT HEADINGS: Helicobacter pylori, Virulence genes