Myanmar Health Sciences Research Journal
Volume 28, Number 1
TITLE: Quality Assessment of Antimalarials in Two Border Areas (Tamu and Muse)
AUTHOR: Khin Chit, Myint Han, Thaung Hlaing, Theingi Zin, Lu Lu Kyaw Tin Oo, Tin Myo Khine, Phyu Sin Ko & San Myat Mon
SOURCE: Myanmar Health Sciences Research Journal, Vol. 28, No. 1, 2016
ABSTRACT: Antimalarials in Myanmar are being produced and procured through various mechanisms by International Organizations, NGOs, Disease Control Programs and the vast private sector. Poor-quality lives saving medicines are a major public health threat. The Quality Assurance and monitoring of these antimalarials is essential in tackling the emerging resistant malaria parasites. The study conducted post-marketing surveillance in two border areas, Tamu (Myanmar-India border) and Muse (Myanmar-China border) from March 2014 to July 2014. The aim of the study was to detect the counterfeit and substandard antimalarial drugs in public and private sectors in border areas. Antimalarial drugs were collected randomly from wholesale private pharmacies and public pharmacies of township general hospitals. A total of 51 samples of antimalarials were collected and analyzed with thin layer chromatographic method by using GPHF-Minilab for screening test and with High Performance Liquid Chromatographic method according to USP-37 and International Pharmacopoeia 2011 for confirmatory test. Out of 51 samples, 12 samples (23.5%) were non-conformant with the pharmacopoeia specifications such as 6 samples of chloroquine, 3 samples of quinine sulfate, 2 samples of mefloquine and 1 sample of quinine injection. Out of 51 samples, 22 samples or 43% were found to be unregistered. Although this is the preliminary monitoring of antimalarials by DFDA, the results indicate that quality assurance and monitoring activities on antimalarials should be strengthened with the responsible authorities to ensure the quality of antimalarials and to prevent the emergence of drug- resistant strains in Myanmar.
SUBJECT HEADINGS: Antimalarials, GPHF-Minilab, High performance liquid chromatographic