Myanmar Health Sciences Research Journal
Volume 28, Number 1
TITLE: Survival of HIV Infected Children on Antiretroviral Therapy
AUTHOR: Khaing Lay Mon, Khaymar Mya & Ko Ko Zaw
SOURCE: Myanmar Health Sciences Research Journal, Vol. 28, No. 1, 2016
ABSTRACT: The aim of this study was to assess the survival of HIV infected children on Antiretroviral Therapy (ART) at Specialist Hospital, Mingalardon, Yangon and 300-bedded Children’s Hospital, Mandalay. Retrospective cohort study was carried out among HIV positive children (under 15 years aged) with ART from 1st January 2005 to 31st August 2012. Information on relevant variables was collected from patients’ ART cards and registries. Life table was used to estimate the cumulative survival of children. Kaplan-Meier survival curves were constructed and assessed the difference between the curves using the log ranks test. A total of 881 records were included in the data analysis. The mean (SD) age at time of diagnosis was 64.14(38.15) months and the mean (SD) age at initiation of ART was 74.9(38.04) months. The median follow-up period was 26 months (IQR=14 to 41 months). At the end of follow-up, 87(9.9%) were dead, 28(3.2%) were loss to follow-up and 15(1.7%) were transferred out to other health facility. Mortality rate was 4.16 deaths per 100-child year of follow-up period. The cumulative probabilities of survival at 3, 6, 12, 24 and 60 months of ART were 0.94, 0.93, 0.92, 0.91 and 0.89, respectively. Majority (86.2%) of the deaths occurred within the first year of treatment. There was a high rate of mortality within one year after initiation of ART. Hence, priority should be given to the children during the first year after initiation of ART.
SUBJECT HEADINGS: HIV/AIDS, Paediatric, Survival, Antiretroviral therapy