Myanmar Health Sciences Research Journal
Volume 28, Number 1
TITLE: Clinical Outcomes of Patients with Mild Acute Pancreatitis Treated without Antibiotics
AUTHOR: Htwe Htwe Hlaing, Tin May Saw, Kyaw Naing, Tin Latt & Shein Myint
SOURCE: Myanmar Health Sciences Research Journal, Vol. 28, No. 1, 2016
ABSTRACT: The purpose was to study the clinical outcomes of patients with mild acute pancreatitis treated without antibiotics.Study design was hospital-based prospective descriptive study, including all patients admitted with mild acute pancreatitis within one year study period and who consented to treat without antibiotics were assigned. All patients diagnosed as mild acute pancreatitis having CRP level not more than 130 mg/l were treated without antibiotics. Clinical outcomes were evaluated starting from clinical diagnosis and determined duration of abdominal pain, total analgesic requirement, pattern of body temperature, return of bowel functions, duration of hospital stay and proportion of patients who required antibiotics in mild acute pancreatitis. Forty-one patients were enrolled. Male to female ratio was 3:1. The commonest age group was 20-39 years (26 patients, 63.41%). The result of this study showed that duration of abdominal pain was longer in gall stone related pancreatitis and antibiotics were given in those patients. Total analgesic requirement varied according to the intensity of pain and patient awareness. Patients with unresolved fever (swinging fever pattern) needed antibiotics in their treatment. Normal bowel function was present in half of the patients starting from admission. Patients with swinging fever pattern were stayed for longer duration due to progress of disease. Longer duration of hospital stay was due to pain. Antibiotics were not required in 75% of patients. The failure rate was 25%. Thus, antibiotics were not required in treatment of mild acute pancreatitis. Antibiotics requirement could be involved in treatment progression of gall stone related pancreatitis and patients with comorbid conditions. Further trial is needed to evaluate clinical outcomes of patients.
SUBJECT HEADINGS: Mild acute pancreatitis, Antibiotics, CRP, Clinical outcomes, Biliary related pancreatitis