Myanmar Health Sciences Research Journal
Volume 28, Number 1
TITLE: Serum Coenzyme Q10 Level, Blood Lactate/Pyruvate Ratio and Serum Cholesterol Level in Patients on Statin Therapy
AUTHOR: Min Min Than, Khin Thidar, May Pyone Kyaw & Theingi Myint
SOURCE: Myanmar Health Sciences Research Journal, Vol. 28, No. 1, 2016
ABSTRACT: The widely used cholesterol lowering drug, statin inhibits the synthesis of coenzyme Q10 as it shares the common biosynthetic pathway with the cholesterol. Since coenzyme Q10 is an important component of mitochondrial electron transport chain, the reduced synthesis of coenzyme Q10 impairs the oxidative capacity of electron transport chain which can be reflected by blood lactate/pyruvate level. Therefore, the present study aimed to evaluate serum coenzyme Q10 level, blood lactate/pyruvate ratio and serum cholesterol level in thirty hypercholesterolaemic patients with ischemic heart disease before commencing and 2 and 4 months after statin therapy. Serum coenzyme Q10 level was determined by ELISA and blood lactate, pyruvate and serum cholesterol levels were determined by colorimetric method. All data were analyzed by using ANOVA test. Serum cholesterol levels of 2 months (167.17±31.27 mg/dl) and 4 months (154.95±32.49 mg/dl) after statin therapy were significantly lowered than that of before therapy (230.40±31.29 mg/dl). Serum coenzyme Q10 levels of 2 months (0.6±0.15 μg/l) and 4 months (0.54±0.15 μg/l) after statin therapy were found to be significantly decreased than that of before therapy (0.81±0.24 μg/l). However, there was no significant difference in blood lactate/pyruvate ratio among 2 months (24.47±5.60), 4 months (27.18±5.60) after statin therapy and before therapy (28.64±4.70). No significant correlations were found among serum cholesterol levels, serum coenzyme Q10 levels and blood lactate/pyruvate ratios (p=0.05). Thus, the statin therapy lowers both serum cholesterol and coenzyme Q10 levels, but does not alter blood lactate/pyruvate ratio.
SUBJECT HEADINGS: Statin, Coenzyme Q10, Mitochondrial dysfunction