Myanmar Health Sciences Research Journal
Volume 28, Number 1
TITLE: Anti-inflammatory Activity of Alstonia scholaris (L.) R. Br. on Carrageenan Induced Albino Rats
AUTHOR: Swe Swe, Thein Zaw Linn, Aye Aye Phyu, Kyaw Min Aung, Aye Aye Tun, Moh Moh Lwin, Zin Nwe Soe, Than Maung & Yi Yi Myint
SOURCE: Myanmar Health Sciences Research Journal, Vol. 28, No. 1, 2016
ABSTRACT: Joint pain and inflammation are common problem in medical practice. Alstonia scholaris (L.) R. Br. (Taungmayoe) is traditionally used in arthritis and diabetes mellitus in Myanmar. This study aimed to determine the anti-inflammatory activity of Alstonia scholaris (L.) R. Br. on carrageenan induced inflammation in albino rats. Rats were randomly divided into five groups and treated with single oral administration of the bark powder of test plant 1.6 g/kg, 2.4 g/kg, 3.2 g/kg body weight, negative control vehicle (distilled water) 10 ml/kg and positive control acetyl salicylic acid (aspirin) 300 mg/kg, respectively. Then, the basal paw volumes were measured immediately prior to the inducing of carrageenan and thereafter at 1 hour, 2 hour, 3 hour, 4 hour, 5 hour and 6 hour by using plethysmometer. The mean paw volumes of rats were significantly reduced in the highest dose 3.2 g/kg) of the test powder starting from 2 hour, 3 hour, 4 hour (p<0.01), 5 hour, 6 hour (p<0.001) and the positive control aspirin also caused paw volume reducing starting at 1 hour (p<0.05), 2 hour (p<0.000), 3 hour (p<0.01), 4 hour, 5 hour, 6 hour (p<0.000) compared to that of negative control group. The percent (%) inhibition on carrageenan induced inflammation in rats was highest in the concentration of the test powder 3.2 g/kg at 6 hour (71%) though it was less than aspirin (87%).Therefore, the present study supports the traditional use of the test plant in acute inflammatory activity.
SUBJECT HEADINGS: Alstonia scholaris, Anti-inflammatory, Carrageenan, Paw edema