Myanmar Health Sciences Research Journal
Volume 4, Number 2
TITLE: The effect of cobra (Naja naja) venom on blood coagulation/fibrinolysis system and on red blood cells.
AUTHOR: Khin Ei Han; Than Than; Myat Mon Oo; Ni Win
SOURCE: Myanmar Health Sciences Research Journal. 1992; 4(2): 100-104
ABSTRACT: The effects of cobra (Naja naja) venom on blood coagulation , fibrinolysis and red blood cells were studied in vitro. Cobra venom had dose dependent inhibition effect on both intrinsic and extrinsic coagulation pathways. It also had inhibitive destructive effect on the individual clotting factors V, VII and X but on effect on the action of thrombin on fibrinogen. However, cobra venom had neither fibrinolytic nor fibrinogenolytic effect even at high venom concentration (10 mg/ ml). Furthemore, cobra venom had direct haemolytic effect shown by increased red cell
SUBJECT HEADINGS: Cobra Venoms. Blood Coagulation. Fibrinolysis. Blood Cells.