Myanmar Health Sciences Research Journal


Archives   2011

Myanmar   Health   Sciences   Research   Journal

Volume   23,  Number   2

TITLE:   Glucose-6-phosphate dehydrogenase enzyme deficiency in Kayah & Rakhin states.
AUTHOR:   Nwe Nwe Oo; Myat Phone Kyaw; Ye Htut; Ni Ni Zaw; Phyo Zaw Aung
SOURCE:   Myanmar Health Sciences Research Journal. 2011; 23(2): 127-130
ABSTRACT:   The aim of the study was to detect glucose-6-phosphate dehydrogenase(G-6-PD) enzyme deficiency in healthy male and female subjects in Kayah and Rakhine states. In male subjects, G-6-PD enzyme deficiency was detected by a qualitative test i.e., methaemoglobin reduction test (Brewer’s test), followed by a semiquantitative test of agarose gel electrophoresis. For detection of enzyme deficiency in female subjects, the cytochemical staining method of Cornelis, Van-Nooden and Vogels was used. It is a method for staining G-6-PD activity in individual erythrocyte. The study was done in subjects who lived in Demowsoe of Kayah State and Sittway of Rakhine State during the period of April and May 2010. In Kayah State, out of 152 male subjects, 1.3% (n=2) were mild deficient and no severely deficient person was detected. In 252 female subjects, 0.41% (n=1) was mild deficient and 1.98% (n=5) were severely deficient. In Rakhine State, 151 male subjects were recruited and out of these patients 3.97% (n=6) were mild deficient and in 250 female subjects, 0.8% (n=2) were mild deficient. The subject with severe enzyme deficiency was not found. In treatment of malaria infection, the antimalarial drug primaquine can cause haemolysis in G-6-PD enzyme deficient patients. The finding of this study may be useful for primaquine treatment of hypnozoite stage in Plasmodium vivax and gametocyte stage in Plasmodium falciparum malaria infections.
SUBJECT HEADINGS:   Glucosephosphate Dehydrogenase.
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