Myanmar Health Sciences Research Journal
Volume 23, Number 2
TITLE: Acute and sub-acute toxicity of Cuminnum cyminum Linn.(Ziya) seeds on laboratory rats.
AUTHOR: Mu Mu Sein Myint; May Aye Than; Yin Min Htun; Win Win Maw; Aye Myint Swe; San San Myint; Myint Myint Khine; Phyu Phyu Win
SOURCE: Myanmar Health Sciences Research Journal. 2011; 23(2): 79-83
ABSTRACT: Cuminum cyminum Linn. (Ziya) seed is one of the most useful spices in Myanmar. It is included in curry powder and some traditional medicine formulations. In acute toxicity test, it was found that there was no toxic symptom in albino mice at the dose of up to 4 gm/kg body weight. In sub-acute toxicity test, three groups of rats were tested orally once daily for 90 days. Group 1 and Group 2 received 3 gm/kg and 1 gm/kg body weight of seed powder. Group 3 received only 10 ml/kg of distilled water and served as control group.On day 91, all three groups were sacrificed and blood was collected for biochemical tests (LFT and urea) and haematological parameters. Internal organs were dissected out, weighed and histo-pathological examinations were done. Sub-acute toxicity test showed that there were no changes of body weight and organ weight in all three groups. There were no significant changes in LFT, urea, complete picture and platelet count when compared with the control group. In histopathological examinations, squamous metaplasia, necrosis and polymorph infiltration were observed at mucosa of small intestine in some high dose treated rats (3 gm/kg body weight). Mild haemorrhage in kidney was also seen in 3 out of 8 rats. There were no significant changes of histopathological examinations in low dose and control groups.
SUBJECT HEADINGS: Toxicity.