Myanmar Health Sciences Research Journal
Volume 24, Number 2
TITLE: Preliminary study of blood glucose lowering effect of Curcuma longa Linn. (Turmeric) Rhizomes on rabbit model.
AUTHOR: Sandar Aung; May Aye Than; Khine Khine Lwin; Mu Mu Sein Myint; Khin Tar Yar Myint; Win Win Maw
SOURCE: Myanmar Health Services Research Journal. 2012; 24(2): 72-78
ABSTRACT: The present study was performed to investigate the phytochemical constituents, physicochemical parameter, acute toxicity and blood sugar lowering effect (antihyperglycaemic effect) of Curcuma longa Linn. (turmeric) rhizomes. Both aqueous and 50% ethanolic extracts of turmeric rhizomes contained alkaloids, flavonoids, glycosides, tannin, phenol, saponins, resin, triterpene and amino acid. The acute toxicity studies of aqueous and 50% ethanolic extracts of turmeric were done on albino mice. It was observed that median lethal dose (LD50) values of aqueous and 50% ethanolic extracts of turmeric were 8.6 g/kg, (confidence limit 7.54 g/kg-9.8 g/kg) and 11.5 g/kg, (confidence limit 8.46 g/kg-15.64 g/kg), respectively. Blood glucose lowering effect of aqueous and 50% ethanolic extracts of turmeric (2.5 g/kg) were investigated on adrenaline-induced hyperglycemic rabbit model by using oral route. The rabbits were made hyperglycemic by injection with 0.15 ml/kg of adrenaline tartrate subcutaneously. In this study, it was found that the aqueous and 50% ethanolic extracts of turmeric produced a significant decrease in blood glucose level in the rabbit model (p<0.05-p<0.01). It was found that blood glucose lowering effect of the 50% ethanolic extract of turmeric rhizomes was greater than that of aqueous extract of turmeric. In comparison of antihyperglycaemic effects of turmeric rhizomes extracts and standard drug glibenclamide, it was found that the antihyperglycaemic effect of the extracts of turmeric rhizomes was the same as that of glibenclamide. Therefore, it could be concluded that the two extracts of Curcuma longa L. rhizomes possess a significant blood glucose lowering effect on adrenaline-induced hyperglycaemic rabbit model.
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