Myanmar Health Sciences Research Journal
Volume 24, Number 1
TITLE: Adherence to the recommended regimen of artemether-lumefantrine for treatment of uncomplicated falciparum malaria in Myanmar.
AUTHOR: Zaw Win Tun; Zaw Lin; Khin Wai; Khin Lin; Myitzu tin Oung; Thar Tun Kyaw; Kyaw Zin Thant
SOURCE: Myanmar Health Services Research Journal. 2012; 24(1): 48-53
ABSTRACT: This study aimed to assess the adherence of six-dose regimen of artemether-lumefantrine (AL), the recommended artemisinin-based combination therapy in uncomplicated falciparum malaria patients in the community. Cross-sectional comparative study was conducted on 248 uncomplicated falciparum malaria patients at four townships in Mandalay Region. Thirty-three percent of the patients (95% CI=27.5-39.1) took the medicine with fatty food. Ten patients (4%, 95% CI=2.2-7.3) were classified as definitely non-adherent. Patients in the probably non-adherent category were 16 (6.5%, 95% CI=4-10.2). Reasons for non-adherence were 18 (69.2%, 95% CI=50-83.5) thought of being cured, 3 (11.5%, 95% CI=4-29) expected rapid cure, 3 (11.5%, 95% CI=4-29) feared of side effects and 2 (7.7%, 95% CI=2.1-24.1) shared the drug with another patient. Two hundred and twenty-two patients (89.5%, 95% CI=85.1-92.7) were probably adherent to the recommended regimen. The youngest age group had significantly higher adherence than the eldest age group had (p=0.02), but no significant differences were seen among other age groups. The background characteristics of patients or caregivers were not associated with probably adherence to recommended regimen of AL. The high level of adherence to AL found in our study is likely to be the result of the effectiveness of the health care programmes and the awareness of malaria among the community members. Miss perception toward the regimen was still present, nevertheless.
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