Myanmar Health Sciences Research Journal
Volume 24, Number 1
TITLE: A study of lipid profile in rheumatoid arthritis.
AUTHOR: Nilar Win; Htun Naing Oo; Chit Soe; Yin Lynn Myint
SOURCE: Myanmar Health Services Research Journal. 2012; 24(1): 20-24
ABSTRACT: The aim of this study was to evaluate significance of lipid profile in rheumatoid arthritis patients. Forty rheumatoid arthritis patients and forty of age- and sex-matched healthy volunteers were included in the study. Serum lipid profile (total cholesterol, triglyceride, low density lipoprotein, and high density lipoprotein) was determined using spectrophotometer. Disease activity was assessed by using disease activity score (DAS-28). Rheumatoid arthritis patients had mean total cholesterol level of 189.27Ã‚Â±41.60 mg/dl, triglyceride level of 134.07Ã‚Â±37.05 mg/dl, low-density lipoprotein level of 117.35Ã‚Â±34.61 mg/dl, and high-density lipoprotein level of 45.02Ã‚Â±7.79 mg/dl. Normal healthy volunteers had mean total cholesterol level of 177.53 Ã‚Â±26.67 mg/dl, triglyceride level of 76.69Ã‚Â±24.82 mg/dl, low-density lipo-protein level of 100.87Ã‚Â±23.49 mg/dl, and high-density lipoprotein level of 61.03Ã‚Â±9.34 mg/dl. Serum triglyceride and low-density lipoprotein were significantly high in rheumatoid arthritis (p<0.01 and p<0.05, respectively) whereas serum high-density lipoprotein level was significantly low in rheumatoid arthritis (p<0.01). Mean atherogenic index of rheumatoid arthritis was 4.30Ã‚Â±1.05 while that of normal healthy volunteers was 3.00Ã‚Â±0.74 and the difference was statistically significant (p<0.01). Lipid profile pattern was not significantly and strongly correlated with disease activity score. Rheumatoid arthritis is associated with adverse lipid profile.
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