Myanmar Health Sciences Research Journal
Volume 25, Number 3
TITLE: Influence of Low-Fat Food on Absorption of Piperaquine in Myanmar Healthy Volunteers
AUTHOR: Nyi Nyi Win; Marlar Myint; Khin Thane Oo; Yamin Ko Ko; Moe Moe Aye; Mya Mya Moe; Swe Swe Aung; Thin Thin Hlaing; Thin Zar Myo
SOURCE: Myanmar Health Sciences Research Journal. 2013; 25(3): 202-206
ABSTRACT: Artemisinin-based combination therapies (ACTs) are now recommended as the drugs of choice for treatment of uncomplicated Plasmodium falciparum malaria and fixed-dose combination are highly preferable (WHO 2006, 2010). Piperaquine is a resurgent antimalarial drug which has been interested as a partner drug in ACTs. Piperamisinin is an oral fixed-dose combination of dihydroartemisinin-piperaquine (each tablet contains 350 mg of piperaquine and 50 mg of dihydroartemisinin). The present study has investigated the effect of low-fat food on absorption of piperaquine in Myanmar healthy volunteers after oral administration of piperamisinin. Absorption of piperaquine after oral administration of piperamisinin three tablets in fasting state was compared with that of non-fasting state with carbohydrate meal (low-fat food) in 14 Myanmar healthy volunteers. Wash-out period was allowed for three months between the two conditions. Serum piperaquine concentrations were assayed by minor modification of HPLC-UV method of Hung. The absorptions of piperaquine were not significantly different between the above two conditions. It was concluded that low-fat food did not interfere the absorption of piperaquine in Myanmar healthy volunteers. Therefore, useful advice could be given in pharmaceutical care of piperaquine-based ACTs that a meal could be taken before or with the drug by malaria patients who are prone to get hypoglycaemia during acute illness.
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