Myanmar Health Sciences Research Journal
Volume 25, Number 3
TITLE: Single Nucleotide Polymorphisms in Multidrug Resistance 1 (mdr1) Gene of Plasmodium vivax Isolates in Thanbyuzayat Township, Myanmar.
AUTHOR: Mya Mya Lwin; Mallika Imwong; Ye Htut
SOURCE: Myanmar Health Sciences Research Journal. 2013; 25(3): 161-165
ABSTRACT: Thirty-two laboratory-confirmed Plasmodium vivax samples were collected before treatment with chloroquine and primaquine at the Out-patient Department (Malaria), Thanbyuzayat Township Hospital, Thanbyuzayat Township, Myanmar during 2008. Multidrug resistance 1 (mdr1) gene point mutations were evaluated by PCR and direct sequencing. Compared to Sall as the reference wild type, three nonsynonymous mutations at codon 958, 976 and 1076 of Pvmdrl gene were found in this study. Point mutation at codon 976 (Y to F, tyrosine for phenylalanine substitution) was observed in 7 samples (21.9%) and the F to L change (phenylalanine for leucine substitution) at codon 1076 was seen in 14 samples (43.8%), although P. vivax is still sensitive to chloroquine in this region.
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