Myanmar Health Sciences Research Journal
Volume 25, Number 2
TITLE: Pattern of Metastasis in Metastatic Breast Cancer Patients Attending Medical Oncology Ward, Yangon General Hospital.
AUTHOR: Than Than Aye; Yae Chan; Han Win; Kyaw Oo; Khin Thinn Mu
SOURCE: Myanmar Health Sciences Research Journal. 2013; 25(2): 149-155
ABSTRACT: A cross-sectional descriptive study was carried out in Medical Oncology Ward, Yangon General Hospital during 2010 to explore the metastatic pattern among breast cancer patients. A total of 85 metastatic breast cancer patients were interviewed using pre-tested questionnaire and medical records were also reviewed. Their ages ranged from 34 years to 79 years and majority were female (98%). Seventy-four percent of patients had axillary nodal involvement and 51% had T4 tumour size at the time of primary tumour diagnosis, More than one third (37%) were asymptomatic at time of diagnosis of metastasis. In this study, breast cancer metastasized most commonly to lung (51%) followed by liver (29%), bone (26%) and brain (6%), Metastasis was not present in 67% at time of primary tumour diagnosis with median metastasis tree interval of 19 months (2 months-168 months). There was a significant association between increased frequency or lung metastases and regional recurrence (p=0.03) and border- line association with ductal type (p=0.05). These patients also had significantly shorter metastasis free interval (MFI<5 years; p=0.02) than those with extra-pulmonary metastasis. Patients with bone metastasis were significantly more symptomatic (p=0.03) than other patients. Hepatic metastases were observed more commonly in younger age group (Ã¯â€šÂ£50 years; p=0.01) and premenopausal group (p=0.05). In this study, sites of metastasis were found to have no association with INM staging and Bloom Richardson grade. This study highlighted the factors related to site of metastasis in breast cancer patients.
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