Myanmar Health Sciences Research Journal

Archives   2015

Myanmar   Health   Sciences   Research   Journal

Volume   27,  Number   2

TITLE:   Clinical Outcomes of Patients on Anti-Retroviral Therapy
AUTHOR:   Aung Sann Oo, Moe Kyaw Myint, Kyaw Thu Soe, Aung Thu, Yadanar Aung & Kyaw Zin Thant
SOURCE:   Myanmar Health Sciences Research Journal. 2015; 27(2): 94-99
ABSTRACT:   Under National AIDS-STD Prevention and Control Programme (NAP), Pyin Oo Lwin Hospital has provided anti-retroviral therapy (ART) for patients with HIV/AIDS since 2007. The clinical outcomes of HIV/AIDS in adults on ART were prospectively studied. According to National Guideline (2007), the patients with World Health Organization (WHO) clinical Stage III, those with Stage IV and those with CD4 cell count <200 cells/mm3 were selected for ART. Total 78 patients who admitted to NAP clinic of the hospital between December 2007 and April 2012 involved in this study. Among them, 62.8% were males. Mean age was 37.3 years. The majority (77%) of studied patients stated that possible risk factor for transmission of HIV into them was heterosexual contact. At baseline, 74.4% were ART-naive, mean body mass index (BMI) was 18.8 kg/m2 and 30.8% had WHO stage III or IV. Median CD4 cell count at baseline was 128 cells/mm3. At follow-up (median 29 months), 56(71.8%) were still on ART, 17(21.8%) had died, 2(2.6%) were transferred, and 3(3.8%) were lost to follow-up. Ten of 17 deaths occurred during 6 months after ART initiation. Median CD4 gain at 1 year, 2 years and 4 years were +130 cells/mm3, +136 cells/mm3 and +167 cells/mm3, respectively. The Kaplan-Meier survival estimates at 1, 2, 3 and 4 years were 84.6% (95% CI 76.9-93.0), 79.2% (95% CI 70.2-89.4), 74.4% (95% CI 64.1-86.3) and 74.4% (95% CI 64.1-86.3), respectively. As a conclusion, the positive outcomes were achieved successfully in the beginning of ART provision in Pyin Oo Lwin General Hospital.

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