Myanmar Health Sciences Research Journal

Download Citation



It was a cross-sectional descriptive study conducted at the Hepatitis Carrier Clinic, Department of Medical Research (DMR) and the Out-patient Department of Liver Medical Unit, Yangon Speciality Hospital (YSH).
A total 130 chronic hepatitis C infected subjects at age of 18 years and above were recruited at Hepatitis Carrier Clinic (DMR) and OPD (YSH) from December 2016 to June 2017.

Pregnant women, patients with concomitant HCV and HBV infections, known history of type 1 diabetes mellitus, history of alcohol abuse, history of regular taking corticosteroid or hydrochlorothiazide, known or suspected case of haemochromatosis or autoimmune disease, known history of pancreatitis or pancreatic tumor, complication of chronic hepatitis infection such as cirrhosis and hepatocellular carcinoma were excluded in this study.

Procedure of the study

All the selected subjects were explained about the study and obtained the written informed consent. History taking, weight and height measurement (BMI calculation) were done according to proforma. Under aseptic condition, 2 ml of venous blood samples were collected from antecubital vein for random plasma glucose test, HbA1c test and liver function test. The subjects who needed to do fasting plasma glucose test were explained about fasting (no caloric intake 8 hrs), and the test was done on next day. The plasma glucose level was measured by using chemical analyzer within 24 hours and HbA1c test was done by NycoCard READER II (Boronate affinity test principle).

Criteria for diagnosis of diabetes14

1.   In persons with symptoms of hypergly- cemia* or hyperglycemic crisis*,

·      Random plasma glucose ≥200mg/dl
(11.1 mmol/l) ) (or)

·      Fasting plasma glucose ≥126mg/dl
(7.0 mmol/l) (or)

·      HbA1C ≥6.5% (48 mmol/mol)

2.   In persons without symptoms of hypergly- cemia or hyperglycemic crisis, diagnosis should not be based on a single test. At least one additional test on another day requires for confirmation.

3.   Known cases of diabetic patients who had already taken oral hypoglycemic drug.

*Hyperglycemic symptoms are frequent urination, increased thirst, blurred vision, fatigue and headache.

*Hyperglycemic crisis symptoms are fruity-smelling breath, nausea and vomiting, shortness of breath, dry mouth, weakness, confusion, coma and abdominal pain.

Data analysis

Data analysis was done by SPSS (version 16). Prevalence and associated factors of diabetes in HCV patients were evaluated in frequency and percentage. The mean values of age, BMI, RBS, HbA1C, ALT and AST among three groups were compared using ANOVA test. Statistical significance was set at p=0.05.

Ethical consideration

The research proposal was submitted to the Ethics Review Committee, Department of Medical Research. The subjects were informed about the objective and details of the procedure of the study before getting consent and have the right to refuse for this research study if they do not want to participate without any disturbance in getting their medical care. The patients were informed and explained about test result and referred for proper management in necessary cases.

Vision : Achieving a healthier nation through application of research findings          Mission Statement : To Develop and promote solutions to the major health problems of Myanmar